Secondary school education – Natural Science High School Nedaye Azadi, Tehran , Iran .

Research Fellow, Veteran Administration Hospital, Roxbury, Harvard University, Boston USA (Expression of the factor VII mutations through mutagenic models).

Intern in the Department of Internal Medicine - San Paolo Hospital, Milan .

Internship in the Department of Internal Medicine – Emergency Medicine-San Paolo Hospital Milan

Resident in the Department of Internal Medicine and Haematology

Fellow in the Department of Internal Medicine and Haematology

Responsible for the haematology out-patient clinic - haemophilia, rare bleeding disorders and thrombosis, Department of Internal Medicine, University of Milan .

Consultant, IRCCS Maggiore Hospital , University of Milan .
Out-patient clinic for haemophilia, rare bleeding disorders and thrombotic thrombocytopenic purpura .

Internal Medicine, Haematology Tutor.

Undergraduate and postgraduate teaching in molecular medicine, Faculty of Biotechnology, University of Milan .

Associate Professor in Internal Medicine , University of Milan .

: Prize awarded to the best scientific communication, 15 th Congress of the Italian Society for Thrombosis and Haemostasis, Naples , September 11-13.

: Young Investigator Award for best scientific communication, 17 th Congress of the International Society on Thrombosis and Haemostasis. Washington DC, August 14-21.

Prize awarded to young scientists, 16 th Congress of the Italian Society Thrombosis and Hemostasis – Milan , May, 2000.

: Malattie rare della coagulazione: studio fenotipico e genotipico delle proteine dlla coagulazione (Rare coagulation disorders: phenotypic and genotypic studies on coagulation proteins).
MURST, University of Milan , Italy (COFIN) - € 47,300.

: Caratterizzazione molecolare dei difetti della metalloproteinasi ADAMTS 13 nelle microangiopatie trombotiche (Molecular characterization of the metalloprotease ADAMTS13 gene in thrombotic microangiopathies). IRCCS Maggiore Hospital , Milan , Italy - € 51,650.

Evaluation of gene polymorphisms associated with thrombosis and pharmocogenomic studies on anticoagulants using new high throughput techniques.
IRCCS Maggiore Hospital , Milan , Italy - € 51,650.

Quantitative and functional assays of the VWF-cleaving protease (ADAMTS-13) for thrombotic thrombocytopenic purpura.
Cariplo Foundation, Milan , Italy - € 70,000.

: Phenotype and genotype characterization of recessively inherited coagulation disorders.
Bayer Hemophilia Awards Program (early career investigator award). USA - $US 200,000.

: Clinical and molecular diagnosis of rare coagulation disorders.
UniCredit Private Bank, Italy - € 13,000.

: Membrane metalloproteinases involved in disorders of haemostasis. MURST, University of Milan , Italy (COFIN) - € 48200 .

: Cardiovascular disease in congenital haemorrhagic defects.
University of Milan , Italy (FIRST) - € 3,500.

: Inflammation genes and development of myocardial infarction at a young age. Retrospective case control study of 2000 cases and 2000 controls enrolled by 125 Italian Coronary Care Unit in eight years.
Cariplo Foundation, Milan , Italy - € 120,000.

: Molecular genetics of hereditary rare bleeding disorders in Indian population.
Ministry of Foreign Affairs, General Directorate for Cultural Promotion and Co-operation - € 40,000.

: Association between polymorphisms in gene encoding for inflammaton protein and juvenile myocardial infarction.
MURST, University of Milan , Italy (COFIN) - € 87,600.

: Development of new quantitative and functional assays of the VWF-cleaving protease (ADAMTS-13) for thrombotic thrombocytopenic purpura.
IRCCS Maggiore Hospital , Milan , Italy - € 51,650.

: Fetal sex determination during the first trimester of pregnancy using non-invasive techniques.
Monzino Foundation, Milan , Italy - € 50,000.

Invited observer, Joint Meeting on Inherited Thrombophilia (organized in Geneva by the World Health Organization and the International Society on Thrombosis and Haemostasis).

Rare coagulation disorders: phenotype and genotype characterization of the coagulation factors - Haemophilia and Thrombosis Centre, Maggiore Hospital, Milan, Italy.

National Hemophilia Workshop, Varanasi, India, 22-24 January, 1999,
Lecture - Rare inherited coagulation cisorders , clinical features and management .

XVI Congreso Intrernacional De Hemostasia Y Trombosis del Grupo CLATH, Lima, Peru, 7-9 August, 1999,
Lecture - Clinical manifestations and management of rare coagulation disorders.

World Federation Of Hemophilia, Montreal, Canada, 16-21 May 2000.
Lecture - Congenital plasma coagulation defects.

World Federation of Hemophilia – Seville, Spain, 24 May 2002,
Lecture - Rare coagulation disorders – factor VII and factor X.

V International Haemophilia Forum. Beirut, Lebanon, 25-28 September 2003.
Lecture - Rare coagulation disorders.

The first International Symposium of Haemostasis & Thrombosis. Shiraz, Iran, 30 November -1 December 2003.
Lectures - Molecular and clinical aspects of rare coagulation disorders in Iran and Diagnosis and management of thrombotic thrombocytopenic purpura.

1 st Saudi International Symposium on Bleeding Disorders, Saudi Arabia, 21-22 February 2004.
Lecture - International registry of rare bleeding disorders.

1 st meeting in Thrombosis and Haemostasis, 27July – 3 August 2004 University Hospital, Khartoum, Sudan.

Indian Society Thrombosis and Transfusion Medicine 45 th Annual Conference, 18-20 November 2004, Vellore, India.

Molecular Biology in Hemophilia and Thrombosis, 28 - 29 November 2004, University of Tehran, Imam Komeini Hospital.

XXX th World Congress of the International Society of Haematology 28 September–2 October 2005, Istanbul, Turkey.
Lecture - The role of ADAMTS13 in the new physiopathogenesis of thrombotic thrombocytopenic purpura.

19 th International Congress on Thrombosis, 14-18 May 2006, Tel Aviv, Israel.
Lecture - From clinical and molecular characterisation to a treatment of rare bleeding disorders

Hemophilia 2006, World Federation of Hemophilia World Congress, 21-25 May 2006, Vancouver, Canada.
Chair of sessions - Rare bleeding disorders and molecular genetics diagnosis of Hemophilia.

Peyvandi F , Faioni EM, Moroni GA, Rosti A, Leo L, Moia M. Autoimmune protein S deficiency and deep vein thrombosis after chickenpox.
Thrombosis and Haemostasis 1996; 75: 212-213

Mannucci PM, Duca F, Peyvandi F , Tagliabue L, Merati G, Martinelli I, Cattaneo M. Frequency of factor V Arg506Gln in Italians.
Thrombosis and Haemostasis 1996; 75: 694.

Ardissino D, Peyvandi F , Merlini PA, Colombi E, Mannucci PM. Factor V (Arg506 à Gln) mutation in young survivors of myocardial infarction.
Thrombosis and Haemostasis 1996; 75: 701-702.

Mannucci PM, Mari D, Merati G, Peyvandi F , Tagliabue L, Sacchi E, Taioli E, Sansoni P, Bertolini S, Franceschi C.
Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians.
Arteriosclerosis, Thrombosis and Vascular Biology 1997; 17: 755-759.


Faioni EM, Merati G, Peyvandi F , Bettini P, Mannucci PM.
The G1456 to T mutation in the thrombomodulin gene is not frequent in patients with venous thrombosis.
Blood 1997; 89: 1467.

Peyvandi F , Mannucci PM, Asti D, Abdoullahi M, Di Rocco N, Sharifian R.
Clinical manifestations in 28 Italian and Iranian patients with severe factor VII deficiency.
Hemophilia 1997; 3: 242-246.

Peyvandi F , Tuddenham EGD, Akhtari M, Lak M, Mannucci PM.
Bleeding symptoms in 27 Iranian patients with the combined deficiency of factor V and factor VIII.
British Journal of Haematology 1998: 100: 773-776

Peyvandi F , Mannucci PM, Lak M, Abdoullahi M, Zeinali S, Sharifian R, Perry D. Congenital factor X deficiency: spectrum of bleeding symptoms in 32 Iranian patients.
British Journal of Haematology 1998; 102: 626-628.

Lak M, Sharifian R, Peyvandi F , Mannucci PM.
Symptoms of inherited factor V deficiency in 35 Iranian patients.
British Journal of Haematology 1998; 103: 1067-1069.

Peyvandi F , Jenkins VP, Mannucci PM, Billio A, Zeinali S, Perkins SJ, Perry DJ. Molecular characterization and three-dimensional structural analysis of mutations in 21 unrelated families with inherited factor VII deficiency.
Thrombosis and Haemostasis 2000, 84: 250-257

Peyvand i F , Mannucci PM, Jenkins PV, Lee A, Coppola R, Perry DJ. Homozygous 2bp deletion in the human factor VII gene: a non-lethal mutation that is associated with a complete absence of circulating factor VII.
Thrombosis and Haemostasis 2000, 84: 635-637.

Tagliabue L, Duca F, Peyvandi F .
Apparently dominant transmission of a recessive disease: deficiency of factor VII in Iranian Jews.
Annali Italiani di Medicina Interna 2000, 15: 263-266.

Lak M, Peyvandi F , Mannucci PM.
Clinical manifestations and complications of childbirth and replacement therapy in 385 Iranian patients with type 3 von Willebrand disease.
British Journal of Haematology 2000, 111: 1236-1239.

Baronciani L, Cozzi G, Canciani MT, Peyvandi F , Srivastava A, Federici AB, Mannucci PM.
Molecular characterization of a multiethnic group of 21 patients with type 3 von Willebrand disease.
Thrombosis and Haemostasis 2000, 84: 536-540.

Peyvandi F , Carew JA, Perry DJ, Hanault M, Khanduri U, Perkins SJ, Mannucci PM, Bauer KA.
Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15 base pair insertion in the factor VII gene.
Blood 2001, 97: 960-965.

Asselta R, Duga S, Spena S, Santagostino E, Peyvandi F , Piseddu G, Targhetta R, Malcovati M, Mannucci PM, Tenchini ML.
Congenital afibrinogenemia: mutations leading to premature termination codons in fibrinogen A alpha-chain gene are not associated with the decay of the mutant mRNAs.
Blood 2001; 98: 3685-3692.

Peyvandi F , Asselta R, Mannucci PM.
Autosomal recessive deficiency of coagulation factors.
Reviews in Clinical and Experimental Haematology 2001; 5: 369-389.

Mannucci PM, Gringeri A, Peyvandi F , Di Paolantonio T, Mariani M.
Short-term exposure to high altitude causes coagulation activation and inhibits fibrinolysis.
Thrombosis and Haemostasis 2002, 87: 342-343.

Peyvandi F , Menegatti M, Santagostino E, Akhavan S, Uprichard J, Perry DJ, Perkins SJ, Mannucci PM.
Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency.
British Journal of Haematology 2002, 117: 685-692.

Peyvandi F , Lak M, Mannucci PM.
Factor XI deficiency in Iranians: its clinical manifestations in comparison with those of classic hemophilia.
Haematologica 2002, 87: 512-514.

Peyvandi F , Duga S, Akhavan S, Mannucci PM.
Rare coagulation deficiencies.
Haemophilia 2002, 8: 308-321.

Tripodi A, Peyvandi F , Chantarangkul V, Menegatti M, Mannucci PM.
Relatively poor performance of clinical laboratories for DNA analyses in the detection of two thrombophilic mutations-A cause for concern.
Thrombosis and Haemostasis 2002, 88: 690-691

Peyvandi F , Spreafico M, Karimi M, Zeinali S, Mannucci PM.
Allele frequency of CYP2C9 gene polymorphisms in Iran.
Thrombosis and Haemostasis 2002, 88: 874-875

Peyvandi F , Cristofaro RD, Akhavan S, Carew JA, Landolfi R, Bauer KA, Mannucci PM.
Two naturally occurring mutations on FVII Gene (S363I-W364C) altering intrinsic catalytic activity.
Thrombosis and Haemostasis 2002, 88: 750-755.

Spena S, Duga S, Asselta R, Malcovati M, Peyvandi F , Tenchini ML.
Congenital afibrinogenemia: first identification of splicing mutations in the fibrinogen B b -chain gene causing activation of cryptic splice sites.
Blood 2002, 100: 4478-4484.

Al Dieri RA, Peyvandi F , Santagostino E, Giansily M, Mannucci PM, Schved JF, Beguin S, Hemker CH.
The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding.
Thrombosis and Haemostasis 2002, 88: 576-582.

Asselta R, Spena S, Duga S, Peyvandi F , Malcovati M, Mannucci PM, Tenchini ML.
Analysis of Iranian patients allowed the identification of the first truncating mutation in the fibrinogen B b -chain gene causing afibrinogenemia.
Haematologica 2002, 87: 855-859.

Akhavan S, De Cristofaro R, Peyvandi F , Lavoretano S, Landolfi R, Mannucci PM.
Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype.
Blood 2002, 100: 1347-53.

Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group.
No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age.
Circulation 2003; 107:1117-1122

Duga S, Montefusco MC, Asselta R, Malcovati M, Peyvandi F , Santagostino E, Mannucci PM, Tenchini ML.
Arg2074Cys missense mutation in the C2-domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein.
Blood 2003, 101: 173-177.


Mannucci PM, Peyvandi F and Ardissino D.
Risk of myocardial infarction and polymorphisms in candidate genes.
N Engl J Med . 2003; 348: 1176-1177; authors' reply 1176-1177.

Mannucci PM, Karimi M, Mosalaei A, Canciani MT , Peyvandi F .
Patients with localized and disseminated tumors have reduced but measurable levels of ADAMTS-13 (von Willebrand factor cleaving protease).
Haematologica 2003; 88: 454-458.

Baronciani L, Cozzi G, Canciani MT, Peyvandi F , Srivastava A, Federici AB, Mannucci PM.
Molecular defects in type 3 von Willebrand disease: updated results from 40 multiethnic patients.
Blood Cells Mol Dis . 2003; 30: 264-270.

Montefusco MC, Duga S, Asselta R, Malcovati M, Peyvandi F , Santagostino E, Mannucci PM, Tenchini ML.
Clinical and molecular characterization of 6 patients affected by severe deficiency of coagulation factor V: Broadening of the mutational spectrum of factor V gene and in vitro analysis of the newly identified missense mutations.
Blood 2003;102:3210-3216.

Asselta R, Montefusco MC, Duga S, Malcovati M, Peyvandi F , Mannucci PM, Tenchini ML.
Severe factor V deficiency: exon skipping in the factor V gene causing a partial deletion of the C1 domain.
J Thromb Haemost 2003;1: 1237-1244.

Mannucci PM, Ardissino D, Merlini PA, Peyvandi F .
Vagaries of genetic association studies in myocardial infarction.
Blood 2003;102: 1558-1559.

Lak M, Peyvandi F , Ali Sharifian A, Karimi K, Mannucci PM.
Pattern of symptoms in 93 Iranian patients with severe factor XIII deficiency.
J Thromb Haemost 2003; 1: 1852-1853.

Garagiola I, Palla R and Peyvandi F .
Pitfalls in molecular diagnosis in a family with severe factor VII (FVII) deficiency--misdiagnosis by direct sequence analysis using a PCR product.
Prenat Diagn 2003;23:731-734.

Spreafico M, Peyvandi F , Pizzotti D, Moia M, Mannucci PM.
Warfarin and acenocoumarol dose requirements according to CYP2C9 genotyping in North-Italian patients.
J Thromb Haemost 2003; 1: 2252-2253

Spena S, Asselta R, Duga S, Malcovati M, Peyvandi F , Mannucci PM, Tenchini ML.
Congenital afibrinogenemia: intracellular retention of fibrinogen due to a novel W437G mutation in the fibrinogen B beta-chain gene.
Biochim Biophys Acta 2003; 1639: 87-94.

Asselta R, Duga S, Spena S, Peyvandi F , Castaman G, Malcovati M, Mannucci PM, Tenchini ML.
Missense or splicing mutation? The case of a fibrinogen B{beta}-chain mutation causing severe hypofibrinogenemia.
Blood 2004; 103: 3051-3054.

Peyvandi F , Tagliabue L, Menegatti M, Karimi M, Komaromi I, Katona E, Muszbek L, Mannucci PM.
Phenotype-genotype characterization of 10 families with severe a subunit factor XIII deficiency.
Hum Mutat 2004; 23: 98.

De Cristofaro R, Akhavan S, Altomare C, Carotti A, Peyvandi F , Mannucci PM. A natural prothrombin mutant reveals an unexpected influence of the A-chain's structure on the activity of human alpha -thrombin.
J Biol Chem 2004; 279: 13035-13043.

Peyvandi F , Spreafico M, Siboni SM, Moia M, Mannucci PM. CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy.
Clin Pharmacol Ther. 2004; 75: 198-203.

Mannucci PM, Duga S, Peyvandi F .
Recessively inherited coagulation disorders.
Blood 2004;104:1243-1252.

Karimi M, Peyvandi F, Siboni S, Ardeshiri R, Gringeri A, Mannucci PM. Comparison of attitudes towards prenatal diagnosis and termination of pregnancy for haemophilia in Iran and Italy .
Haemophilia 2004; 10: 367-369.

Menegatti M, Karimi M, Garagiola I, Mannucci P, Peyvandi F .
A rare inherited coagulation disorder: combined homozygous factor VII and factor X deficiency.
Am J Hematol . 2004; 77: 90-91.

D'Andrea G, Bossone A, Lupone MR, Peyvandi F , Maisto G, Perricone F, Grandone E, Margaglione M.
Molecular characterization of a factor VII deficient patient supports the importance of the second epidermal growth factor-like domain.
Haematologica . 2004; 89: 979-984.

Toogeh G, Sharifian R, Lak M, Safaee R, Artoni A, Peyvandi F .
Presentation and pattern of symptoms in 382 patients with Glanzmann thrombasthenia in Iran .
Am J Hematol . 2004; 77: 198.

Spena S, Duga S, Asselta R, Peyvandi F , Mahasandana C, Malcovati M, Tenchini ML.
Congenital afibrinogenaemia caused by uniparental isodisomy of chromosome 4 containing a novel 15-kb deletion involving fibrinogen Aalpha-chain gene.
Eur J Hum Genet . 2004; 12: 891-8.

P eyvandi F , Ferrari S, Lavoretano S, Canciani MT, Mannucci PM.
von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura.
Br J Haematol . 2004; 127: 433-9.

Zadra G, Asselta R, Malcovati M, Santagostino E, Peyvandi F , Mannucci PM, Tenchini ML, Duga S.
Molecular genetic analysis of severe coagulation factor XI deficiency in six Italian patients.
Haematologica . 2004; 89: 1332-40.

P eyvandi F , De Cristofaro R, Garagiola I, Palla R, Akhavan S, Landolfi R, Mannucci PM.
The P303T mutation in the human factor VII (FVII) gene alters the conformational state of the enzyme and causes a severe functional deficiency.
Br J Haematol . 2004; 127: 576-84.

Akhavan S, Miteva MA, Villoutreix BO, Venisse L, Peyvandi F , Mannucci PM, Guillin MC, Bezeaud A.
The critical role of Gly25 in the B chain of human thrombin.
J Thromb Haemost . 2005; 3: 139-45.

Mannucci PM, Bernardinelli L, Foco L, Galli M, Ribichini F, Tubaro M, Peyvandi F.
Tissue plasminogen activator antigen is strongly associated with myocardial infarction in young women.
J Thromb Haemost . 2005; 3: 280-6.

Mariani G, Herrmann FH, Dolce A, Batorova A, Etro D, Peyvandi F , Wulff K, Schved JF, Auerswald G, Ingerslev J, Bernardi F;
International factor VII Deficiency Study Group. Clinical phenotypes and factor VII genotype in congenital factor VII deficiency.
Thromb Haemost . 2005; 93: 481-487.

Germanos-Haddad M, de Moerloose P, Boehlen F, Peyvandi F , Neerman-Arbez M.
Homozygosity for a Thr575Met missense mutation in the catalytic domain associated with factor XI deficiency.
Haematologica . 2005; 90: 418-9.

De Cristofaro R, Peyvandi F , Palla R, Lavoretano S, Lombardi R, Merati G, Romitelli F, Di Stasio E, Mannucci PM.
Role of chloride ions in the modulation of the interaction between von Willebrand factor and ADAMTS-3.
J Biol Chem . 2005; 280: 23295-302.

Peyvandi F , Bernardinelli L, Martini CH, Celli P, Mannucci PM.
Factor VII gene polymorphisms are not associated with myocardial infarction in young women.
J Thromb Haemost . 2005; 3: 803-4.

Rieger M, Mannucci PM, Hovinga JA, Herzog A, Gerstembauer G, Konetschny C, Zimmerman K, Scharrer I, Peyvandi F , Galbusera M, Remuzzi G, Bohm M, Plaimauer B, Lammle B, Scheiflinger F.
ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases.
Blood . 2005; 106:1262-1267.

Tripodi A, Chantarangkul V, Menegatti M, Tagliabue L, Peyvandi F .
Performance of clinical laboratories for DNA analyses to detect thrombophilia mutations.
Clin Chem . 2005, 51:1310-1.

Mohanty D, Ghosh K, Shetty S, Spreafico M, Garagiola I, Peyvandi F .
Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency of factor V and VIII.
Am J Hematol . 2005; 79: 262-266.

Peyvandi F , Garagiola I, Palla R, Marziliano N, Mannucci PM.
The role of the 2 adenine (g.11293_11294insAA) insertion polymorphism in the 3' untranslated region of the factor VII (FVII) gene: Molecular characterisation of patient with severe FVII deficiency.
Hum Mut (in press)

Peyvandi F , Lavoretano S, Palla R, Valsecchi C, Merati G, De Cristofaro R, Rossi E, Mannucci PM.
Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity.
Hum Mut ( accepted )